Cucamonga comes from a Tongva place name that probably means "sandy place".
Cucamonga has always been recognized as a funny-sounding place name, among such exotic places as Timbuktu and Bora Bora. One of the catch-phrases of the radio show "The Jack Benny Program" involved a train announcer (Mel Blanc) who said over the loudspeaker, "Train now leaving on track five for Anaheim, Azusa, and Cuc (pronounced cuke)... amonga," taking progressively longer pauses between "Cuc" and "amonga." Part of the joke, for the Los Angeles audience, was that no such train route existed. Jack Benny Drive, a small street in the city, is named as a tribute to "The Jack Benny Program". (Coincidentally, the city also has a Rochester Avenue, which is very likely not named for the character portrayed by Eddie Anderson on the Jack Benny Program.) In one of his many popular media crossovers, Blanc used that same catch phrase in Daffy Duck's voice in the 1948 Merrie Melodies cartoon "Daffy Duck Slept Here" and later in Bugs Bunny's voice in a 1960s Looney Tunes cartoon. In an episode of The Simpsons, Krusty the Clown mentioned Rancho Cucamonga, along with Walla Walla, Keokuk, and Seattle, as funny place names.